Improving NDT with Automatic Test Case Generation

The model-driven development defi nes the software development process as a set of iterations to create models and a set of transformations to obtain new models. From this point of view, this paper presents the enhancement of a model- driven approach, called navigational development techniques (NDT), by means of new models and transformations in order to generate test cases. It also states some conclusions from the research work and practical cases in which this approach was used.Ministerio de Ciencia e Innovación TIN2010-20057-C03-02Ministerio de Ciencia e Innovación TIN 2010-12312-

NDT-Driver: A Java Tool to Support QVT Transformations for NDT

Ministerio de Ciencia e Innovación TIN2010-20057-C03-02Ministerio de Ciencia e Innovación TIN2010-12312-EMinisterio de Educación y Ciencia TIN2007-67843-C06-0

Model-driven Test Engineering: A Practical Analysis in the AQUA-WS Project

The effective application of test phases has been one of the most relevant, critical and cost phases in the life cycle of software projects in the last years. During the test phase, the test team has to assure the quality of the system and the concordance with the initial requirements of the system. The model driven paradigm is offering suitable results in some areas and the test phase could be one of them. This paper presents how the application of this paradigm can help to improve this aspect in the functional test generation and it analyses the experience in a real project developed under this approach.Ministerio de Ciencia e Innovación TIN2010-20057-C03-02Ministerio de Ciencia e Innovación TIN 2010-12312-EJunta de Andalucía TIC-578

Aplicación del paradigma MDE para la generación de pruebas funcionales: Experiencia dentro del proyecto AQUA-WS

La fase de pruebas es uno de las más críticas en Ingeniería de Software. Durante esta fase, el equipo de desarrollo tiene que asegurar que el sistema cubre las necesidades y las expectativas del cliente y de los usuarios finales. Este trabajo presenta una visión global de NDT (Navigational Development Techniques) que usa el paradigma MDE (Model-Driven Engineering, ingeniería Guiada por Modelos) para generar casos de pruebas a partir la definición de los requisitos funcionales del proyecto. Este trabajo analiza este proceso y expone cómo se ha aplicado en el proyecto AQUA-WS: un proyecto real que actualmente usa este proceso.Ministerio de Educación y Ciencia TIN2007-67843-C06_03Ministerio de Ciencia e Innovación TIN2010-20057-C03-02Ministerio de Ciencia e Innovación TIN2010-12312-

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood